Advances in macrocyclic chelators for positron emission tomography imaging

In recent years, radiometals have been successfully applied to medicine because of their breadth decay properties and increased production availability. Bifunctional chelators play a key role in radiometal-based radiopharmaceuticals, affecting the labeling, targeting, pharmacokinetics bioconjugations ensuring stable complexation metal vivo. The capacity macrocycles form complexes with extremely high thermodynamics, kinetics, stability compared acyclic continues pique curiosity pharmacists biochemists among all prospective utilized for radiometal chelation. As new imaging modalities therapeutic targets develop, discovery novel ligand structures suitable chemical biological features encourages modification charge properties. Herein, we present comprehensive review developments macrocyclic PET including innovative chelating agents known agent modifications, physical-chemical properties, as well characteristics applications